![]() ![]() Aldosterone is largely responsible for the long-term regulation of blood pressure. The zona glomerulosa cells express a specific enzyme aldosterone synthase (also known as CYP11B2). ![]() The synthesis and secretion of aldosterone are mainly regulated by the renin–angiotensin–aldosterone system. Zona glomerulosa The outermost layer, the zona glomerulosa is the main site for the production of aldosterone, a mineralocorticoid. This anatomic zonation can be appreciated at the microscopic level, where each zone can be recognized and distinguished from one another based on structural and anatomic characteristics. ![]() The adrenal cortex comprises three main zones, or layers that are regulated by distinct hormones as noted below. It is also a secondary site of androgen synthesis. Each zone is responsible for producing specific hormones. It is divided into three separate zones: zona glomerulosa, zona fasciculata and zona reticularis. The adrenal cortex is the outer region and also the largest part of an adrenal gland. ![]()
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